Sunday Night Football prediction, NFL odds, line, spread: 49ers vs. Bills picks from Niners expert on 25-6 run

The red-hot Buffalo Bills will take on the struggling San Francisco 49ers on Sunday Night Football. San Francisco is coming off a 38-10 loss to the Green Bay Packers, while Buffalo is coming off its bye after downing the defending Super Bowl champion Kansas City Chiefs, 30-21. The 49ers (5-6), who are fourth in the NFC West but just one game out of first place, have dropped two in a row and three of five. The Bills (9-2), who are first in the AFC East, have won six consecutive games and are just one game out of the top seed in the conference. Niners quarterback Brock Purdy (shoulder), defensive end Nick Bosa (hip) and offensive tackle Trent Williams (ankle) are on the injury report for the San Francisco. 

Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 8:20 p.m. ET. Buffalo is a 6.5-point favorite in the latest 49ers vs. Bills odds via SportsLine Consensus, while the over/under for total points scored is 44.5. Before you make any Bills vs. 49ers picks, check out the NFL predictions and betting advice from the SportsLine expert Micah Roberts, considering his mastery of picks involving the San Francisco 49ers.

Micah Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos’ book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. Most importantly, Roberts has a read on the pulse of the 49ers. In fact, he is an amazing 25-6 (+1838) on his last 31 picks on games involving San Francisco. Anyone who has followed him on sportsbooks and betting apps is way up.

Now, Roberts has locked in on 49ers vs. Bills and just revealed his coveted NFL picks and predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines for 49ers vs. Bills:

49ers vs. Bills spread: Buffalo -6.549ers vs. Bills over-under: 44.5 points …


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Author : CBS Sports Staff

Publish date : 2024-12-01 15:49:00

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