2025 college football picks, Week 1 odds, lines, best bets by Vegas expert: This parlay could return 6-1

Perhaps the best non-conference slate of the season is on tap as the Week 1 college football schedule features some blockbuster matchups. None are bigger than top-ranked Texas taking on No. 3 Ohio State on Saturday at noon ET. Heisman contenders Arch Manning and Jeremiah Smith will be in the spotlight, and the latest Week 1 college football odds list the Buckeyes as slight 1.5-point favorites. 

No. 8 Alabama (-13.5) vs. Florida State, No. 4 Clemson (-3.5) vs. No. 9 LSU are among the other huge matchups, and the college football odds board has lines of all sizes for games Thursday through Monday. Before locking in any Week 1 college football picks, be sure to see the top Week 1 college football expert picks, predictions and best bets from Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been sports betting — and winning — for more than 30 years. He opened this season with a 2-0 sweep of his best bets in Week 0, building on a 15-6 roll in his SportsLine best bets column that dates back to last season. Anybody who followed him could have been way up.

Now, he has turned his attention to the Week 1 college football odds and is sharing his top betting picks. If you parlay these college football betting picks, you could be looking at a return of around +600. Get his top college football picks at SportsLine, and new users can also target the DraftKings promo code, which offers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

Top Week 1 college football expert predictions

One of Casale’s top Week 1 college football picks: He is backing Alabama to cover the 13.5-point spread against Florida State. By their standards, the Tide were underwhelming in 2024, the first season for head coach Kalen DeBoer….


Source link : https://www.cbssports.com/college-football/news/2025-college-football-picks-week-1-odds-lines-best-bets-by-vegas-expert-this-parlay-could-return-6-1/

Author : Daniel Lewis

Publish date : 2025-08-27 18:09:00

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